| 2021-09-25 15:00:4725. September 2021 |  BBC Münsterland vs. RSV Lahn-Dill  | 49 - 80 | Sporthalle Josefschule | Recap |
| 2021-10-02 20:00:392. Oktober 2021 |  RSB Thuringia Bulls vs. BBC Münsterland | 104 - 54 | Fit-in | Recap |
| 2021-10-09 17:00:529. Oktober 2021 | BBC Münsterland vs. RBC Köln 99ers  | 67 - 59 | Sporthalle Josefschule | Recap |
| 2021-10-16 16:00:5616. Oktober 2021 |  Doneck Dolphins Trier vs. BBC Münsterland | 41 - 59 | Sporthalle am Mäusheckerweg | Recap |
| 2021-10-23 15:00:2323. Oktober 2021 |  BG Baskets Hamburg vs. BBC Münsterland | 66 - 52 | Edel-Optics Arena | Recap |
| 2021-10-30 17:00:3130. Oktober 2021 |  Rhine River Rhinos Wiesbaden vs. BBC Münsterland | 69 - 37 | Sporthalle Klarenthal | Recap |
| 2021-11-06 17:00:256. November 2021 | BBC Münsterland vs. Hannover United  | 51 - 63 | Sporthalle Josefschule | Recap |
| 2021-11-13 17:00:0813. November 2021 | BBC Münsterland vs. ING Skywheelers  | 60 - 53 | Sporthalle Josefschule | Recap |
| 2022-01-15 17:00:2015. Januar 2022 | BBC Münsterland vs. RSB Thuringia Bulls | 45 - 88 | Sporthalle Josefschule | Recap |
| 2022-01-22 17:00:1522. Januar 2022 | RBC Köln 99ers vs. BBC Münsterland | 17:00:1517:00 | Sporthalle Bergischer Ring | Preview |
| 2022-01-23 15:00:5923. Januar 2022 | RSV Lahn-Dill vs. BBC Münsterland | 15:00:5915:00 | August-Bebel-Sporthalle | Preview |
| 2022-01-29 17:00:1229. Januar 2022 | BBC Münsterland vs. Doneck Dolphins Trier | 17:00:1217:00 | Sporthalle Josefschule | Preview |
| 2022-02-19 17:00:0819. Februar 2022 | BBC Münsterland vs. Rhine River Rhinos Wiesbaden | 17:00:0817:00 | Sporthalle Josefschule | Preview |
| 2022-02-26 18:00:0326. Februar 2022 | Hannover United vs. BBC Münsterland | 18:00:0318:00 | Sporthalle der IGS Stöcken | Preview |
| 2022-03-05 18:00:375. März 2022 | ING Skywheelers vs. BBC Münsterland | 18:00:3718:00 | Franz-Böhm-Schule | Preview |
| 2022-03-19 17:00:3219. März 2022 | BBC Münsterland vs. BG Baskets Hamburg | 17:00:3217:00 | Sporthalle Josefschule | Preview |
RSV Lahn-Dill
RSB Thuringia Bulls
Hannover United
Rhine River Rhinos Wiesbaden
RBC Köln 99ers
ING Skywheelers
BBC Münsterland
BG Baskets Hamburg
Doneck Dolphins Trier